akit betegség miatt kezelnek vele sztem annak biztos tördelik a tabit, kizárt hogy 1egészet lenyeletnek vele
oxymetholone terápia:
Case 4-IL.: This
16 year old white male with aplastic anemia had been well until approximately
eighteen months before admission when fatigue, pallor, petechiae and purpura developed
following a relatively prolonged contact with model lacquer and putty. When first
seen elsewhere, he had a pancytopenia and a markedly hypocellular bone marrow. After
two and a half months he had not improved and was started on treatment of predmsone 45
mg. orally and testosterone propionate 90 mg. (2mg/Kg.) sublingually daily. He continued
on this regimen for seven months during which he was transfused every two to three weeks.
Because of lack of improvement, both testosterone and prednisone were then stopped. He
was started on ACTH and thyroid extract, and then splenectomized. Postsplenectomy his
platelets rose to 60,000 to 80,000/mm.3 for six weeks, then returned to the previous 0 to
10,000/mm.3 level. He continued to require biweekly transfusions and had intermittent
hemorrhages prior to his first New England Medical Center Hospitals admission eighteen months after the onset of this aplasia. These admission findings included a marked peripheral
pancvtopenia and a ıerı hvpoplastic bone marrow biopsy.
He was started on oral oxymetholone,
150 ing. per day (3.0/Kg.) and prednisone 10 mg. per (lay. Two weeks later the
oxymetholone was increased to 200 irig. (4.0 mg/Kg.) Two months after initiation of oxyiiwtholone
tIWraI)V his platelet count had risen to a level of 30,000/mm.3, reticulocytes
were 7 per cent, and his hemoglobin had stabilized at 6.7 Cm./100 ml. (Fig. 3). After seven
months on this regimen his hemoglobin was 13.5 Crn./100 ml., white cell count 7,050/mm.3
with 46 per cent neutrophils, and platelets 30,000/mm.3
The dosages of oxymetholone and
prednisone were gradually lowered and stopped completely after eight months of therapy.
Bı’ two months off treatment he was again pancytopenic and he was restarted on oxymetholone
200 mg. per day (4 mg/kg.), and prednisone 10 irig. per day. A second response was
evident after two and a half months with 9 per cent reticulocytes and a hemoglobin increase
to 7.5 Cm./100 ml. Despite a continued reticulocytosis of 4 to 8 per cent, during the next
five months, his hemoglobin remains at 8 Cni./100 ml. His white cell count is 5,600 with
64 per cent neutrophils and platelets stable at 33,000/mm.3 He apparently has a very labile
1)01W marrow an(l may require continuous therapy with androgen.
He has continued to have
completely normal liver-function studies while on high doses of oxymetholone for
over twelve months.forrás:bloodjournal
Téma: Dianabol (Megtekintve 287705 alkalommal)
